In most situations where standard treatment will be given, a Deauville score (DS) of 3 represents a complete metabolic response (CMR). 6. Google Scholar, Fan Y-G, Zhang Y, Yang Z, Ying Z, Zhou N, Liu C, Song Y-Q, Zhu J, Wang X-J (2017) Evaluating early interim fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography with the SUVmax-liver-based interpretation for predicting the outcome in diffuse large B-cell lymphoma. In previous studies,9 12 5-DS of scores of 13 were defined as negative scans, and scores of 45 were considered to be a positive result. The prognostic value of PET/CT evaluation with Deauville score on the recurrence and survival in diffuse large B-cell lymphoma: a multi-institutional study of KROG 17-02 Clin Exp Metastasis . https://doi.org/10.1080/10428190903040048, Laffon E, Marthan R (2017) FDG PET for therapy monitoring in Hodgkins and non-Hodgkins lymphomas: qPET versus rPET. 18F-fluoro-2-deoxyglucosepositron emission tomography has been found to be useful in lymphoma staging, prediction of prognosis and risk stratification of lymphoma patients. However, none of the semiquantitative parameters were correlated with rDS. But it's important to keep in mind that survival rates can vary widely for different types and stages of lymphoma. The Lugano Classification uses the same scale as the Deauville score but refers to it as a 5 point score (5PS). Moskowitz CH. We aimed to compare the performance of SUVmax reduction (SUVmax%) and the PET ratio (rPET) versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients undergoing 18F-FDG PET-CT. Fifty-two patients with biopsy-proven HL . Lesion-to-Liver SUVmax Ratio to Improve the Prognostic Value of the End of Treatment PET/CT in Diffuse Large B-Cell Lymphoma. The authors declare that they have no competing interests. J Radiat Res. (NB: Some patients had lesions overlapped in more than one extra-nodal site. Also, it helped to minimize the side effects of therapy without losing treatment efficacy and reduce the number of chemotherapy cycles to the optimum for each individual patient [2, 4]. The purpose of this study was to evaluate the prognostic role of the semiquantitative ratio Deauville score (rDS), defined as the ratio between target lesion and liver maximum standardized uptake values in children with FDG-avid extra-nodal lymphomas, undergoing interim FDG-PET/CT, and to compare it with the 5-point Deauville score (5p-DS). PubMed National Library of Medicine -. What do the C cells of the thyroid secrete? Annal Nuclear Med 30:588592, Article PET works by using a scanning device (a machine with a large hole at its center) to detect photons (subatomic particles) emitted by a radionuclide in the organ or tissue being examined. PubMed Central Disclaimer. Progression-free survival (PFS) was the end point of our study. Using the ROC curve, we identify the optimal cut-points of rPET with respect to events and chose the rPET cutoff of 1.25, because it had the best specificity (100%) and sensitivity (91.7%) among rPET values. Low grade lymphoma, also known as indolent lymphoma, is usually very slow growing and most often incurable, though many patients respond positively to treatment. HHS Vulnerability Disclosure, Help . These findings are different from results of most of published papers in this context that can be explained by the non-homogeneity of our sample regarding pathological subtypes and stages. Provided by the Springer Nature SharedIt content-sharing initiative. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. 1-2 points: Prognosis, Good (4-year PFS 80%, OS 79%) 3-5 points: Prognosis, Poor (4-year PFS 53%, OS 55%) The R-IPI doesn't recognize risk groups with a perceived B cell lymphoma survival rate of under 50%. Careers. Interim PET was proved to be a surrogate marker of therapeutic outcome, and it has been found to be a useful tool for predicting prognosis and risk stratification of lymphoma patients that consequently has a crucial role in management of such cases [2, 4]. Yhim HY, Park Y, Han YH, Kim S, Kang SR, Moon JH . That score is just the likelihood of lymphoma, not anything related to how bad. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. The visual method depends on visual comparison of FDG uptake between lesions and liver as a reference organ for activity and considered lesions with activity higher than liver to be positive, while the semiquantitative method depends on making a ratio between the most active lesion and liver SUVmax. government site. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. A Deauville score >3 is the most optimal cutoff for interim PET with advanced-stage HL to increase PPV if intensification of therapy is planned, whereas a cutoff <3 is desirable for nonbulky early-stage HL to enhance NPV. Clinical implications of positron emission tomography-negative residual computed tomography masses after chemotherapy for diffuse large B-cell lymphoma. It is a fluorine isotope with a half life of approximately 110 minutes. Oncol. and transmitted securely. Epub 2015 Apr 1. Dabaja BS, Phan J, Mawlawi O, Medeiros LJ, Etzel C, Liang FW, Podoloff D, Oki Y, Hagemeister FB, Chuang H, Fayad LE, Westin JR, Shihadeh F, Allen PK, Wogan CF, Rodriguez MA. Thus, the combination of the information from the PET and CT scans must be used in these patients to differentiate radiation pneumonitis from recurrent tumor. Terms and Conditions, Other tracers are also used in PET to image the tissue concentration. 5, 6, and 7. The interpretation of early response evaluation PET (interim PET done after two cycles of CTH) is a subject of ongoing debate. Lymphoma most often spreads to the liver, bone marrow, or lungs. 2014;32 (27): . During the past 2 decades, 18F-fluoro-2-deoxyglucosepositron emission tomography (FDG-PET) has been found to be useful in providing information about the metabolic activity in patients with lymphoma and has been utilized in lymphoma staging [2, 3]. Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. HY was the major contributor in writing the manuscript. rDS could be suggested as an accurate prognostic factor in children with lymphoma undergoing interim FDG-PET/CT. However, it is a highly treatable disease and the symptoms can be controlled and even reduced with proper treatment and care. Leuk Lymphoma 58:20652073, Mukhtar F, Boffetta P, Risch HA, Park JY, Bubu OM, Womack L, Tran TV, Zgibor JC, Luu HN (2017) Survival predictors of Burkitts lymphoma in children, adults and elderly in the United States during 20002013. "Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment." What is the Deauville 5 point scale? 1left IIb cervical node, 2extensive upper abdominal involvement (periportal, peripancreatic, aortocaval, paraaortic, mesenteric nodes, heterogenous liver and Deauville is a posh seaside resort in Normandy, France. According to the Lugano 2014 guideline, patients with a Deauville score of 1-3 are regarded as negative of disease, while those with a Deauville score of 4 and 5 are positive of disease. It takes advantage of two reference points of the individual patient,which have demonstrated relatively constant uptake on serial imaging. https://doi.org/10.1542/pir.2016-0152, Article Therefore, the present study aimed to evaluate the prognostic impact of interim 18 F-FDG PET/CT assessment according to the Deauville 5-PS score (DS) and SUVmax on survival outcomes of patients . Both values had 100% specificity. The rDS values for patients with no residual lesions in interim PET were1.13, while they ranged between 1.25 and 8.20 in interim positive group. qPET < 2 corresponds to quantitative Deauville score 1-4 (qDS1-4) and qPET 2 corresponds to qDS5. The .gov means its official. The Deauville scale was established during a medical congress a few years ago. Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with SunAgri and INRAE in Avignon between 2019 and 2022. Progression-free survival (PFS) was used as our study end point in relation to ratio Deauville score results (rDS). The Deauville 5PS. We studied the effects of all studied clinical factors, as well as semiquantitative parameters in initial PET, in relation to the rDS. pneumonitis is FDG-avid and can persist for years after therapy. 2014;99 (6): 1107-13. 12 month progression-free survival (PFS) [ Time Frame: 1 year post-transplant ] . Vitolo U, et al. Articles. Data were statistically described in terms of meanstandard deviation (SD), median and range, or frequencies (number of patients) and percentages when appropriate. Minamimoto R, Fayad L, Vose J, Meza J, Advani R, Hankins J, Mottaghy F, Macapinlac H, Heinzel A, Juweid ME, Quon A. Eur J Nucl Med Mol Imaging. Pediatric lymphoma is a common hematological neoplasm, representing the third most frequent childhood malignancy [1]. 41,44 (see HODG-5, page 759) If the Deauville score is 1 to 3, the treatment options include an additional 2 cycles of ABVD (if previously given, for a total . An improved image quality may affect visual scoring systems, including the Deauville score (DS), which is used for clinical assessment of patients with lymphoma. Correspondence to The brighter the nodule appears on the PET scan, the more likely that it is cancer. Lymphocytes are affected in lymphomas. Which type of chromosome region is identified by C-banding technique? MeSH Progression-free survival in prognostic subgroups derived from the quantitative Deauville scale (top) and the SUV max scale (bottom) (Kaplan-Meier analysis). 2023 BioMed Central Ltd unless otherwise stated. Our study was approved by the ethical committee of Faculty of medicine, Cairo University, and the radiation safety committee of national cancer institute had given approval for study design. It is also known as the dose uptake ratio (DUR). The datasets used and analyzed during the current study are available from the corresponding author on reasonable request. The uptake value is represented by pixel or voxel intensity value in the ROI of the image, which is then converted into the activity concentration. By using this website, you agree to our Written informed consents were obtained from all parents. Deauville five-point score (DS) is recommended for response assessment in international guidelines. Metabolic parameters of the highest FDG-avid lesion were recorded for all studied cases as given in Table 4. Chung MJ, Cho WK, Oh D, Eom KY, Kim JH, Kim WC, Lee JH. Ferrari C, Pisani AR, Masi T, Santo G, Mammucci P, Rubini D, Sardaro A, Rubini G. J Clin Med. https://doi.org/10.21147/j.issn.1000-9604.2017.01.07, Nuclear Medicine Department, National Cancer Institute, Cairo University, Cairo, Egypt, Hadeer Yousef Elhamady&Huda Fathy Elsayed, Nuclear Medicine Department, Cairo University, Cairo, Egypt, Bio-Statistics and Cancer Epidemiology Department, National Cancer Institute, Cairo University, Cairo, Egypt, Pediatric Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt, You can also search for this author in [1] The term aggressive NHL refers to those subtypes that grow rapidly (proliferation index > 40%) and would often be fatal within months without appropriate therapy. CT. A contrast enhanced CT is recommended for anatomic staging and radiation therapy planning. Deauville score; Diffuse large B-cell lymphoma; Prognosis; Survival. Patients must sit still in a quite warm room. Results: A totally 145 patients with a mean age of 71.469.26, were evaluated. Only two patients were discordant (positive 5p-DS and rPET<1.25), and neither of these patients had any adverse events and they were completely free till the last follow-up (34 and 35months), and therefore, these could be considered as false positives of 5p-DS. The patient was free till the last follow-up (36months), PET-CT study for an 8-year-old female child presented with fever and abdominal pain. . 2022 Sep 21;11(19):5541. doi: 10.3390/jcm11195541. Bookshelf The mean age of children in interim negative group was 11.23.43, while the mean age of children with interim positive group was 9.332.874. If the cancer spreads regionally, the 5-year survival rate is 94%. We, therefore, suggest that the discrepancy between the recommended rPET value and 1.00 may be related to the rPET MU that should be taken into account [8, 9]. Objective To investigate the prognostic value of SUV and Deauville 5-point scoring (5-PS) in patients with DLBCL. -, Ann Oncol. Particularly, there was a significant difference in PFS between patients with interim score 1-2 and those with score 3. It also causes damage to fast-growing normal cells, including hair cells and cells that make up the tissues in your mouth, gut and bone marrow. The survival outcome in the interim negative group was significantly better than that of the interim positive group with a 3-year PFS of the former group 87.2%, while the 3-year PFS in the latter group has 67.4% (P value=0.002) as illustrated in Table 7 and Fig. Unable to load your collection due to an error, Unable to load your delegates due to an error. Epub 2021 Apr 28. Your prognosis is a best guess at your chances of recovering from lymphoma after treatment. A previous study investigating the impact of posttreatment Deauville score on survival in patients with nodal PTCL showed that a posttreatment Deauville score of 4 or 5 is predictive of poor survival . Doxorubicin, bleomycin, vinblastine, and dacarbazine, Buhtoiarov IN (2017) Pediatric lymphoma. 4. -, J Clin Oncol. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. [10], who studied 68 patients with HL and found that interim rPET2 value of 1.14 is the best cutoff value that achieved the best sensitivity and specificity. Interestingly, with all 3 . 2014 Sep 20;32(27):3059-68 A joined analysis of two prospective randomized trials in newly diagnosed transplant-eligible MM (NDTEMM) patients applied for the first time the Deauville Scores (DS) to focal lesions (FS) and bone marrow uptake (BMS) and showed the liver background (DS < 4) to be the best cut-off to define PET negativity after therapy (Zamagni et al, ASH 2018). statement and Patients with negative 5p-DS and patients with rDS<1.25 had a similar 3-year PFS (87%). J. Nucl. 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