pfizer vaccine becomes dna in liver

With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. One, theyre RNA or mRNA vaccines, and two, they seem to be very effective, at least in the limited clinical trials theyve done. Skip to main content. Our Standards: The Thomson Reuters Trust Principles. WebFDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. In this case, the author compared gene sequences to identify sections of human proteins that have portions similar to SARS-CoV-2 proteins and made a prediction that the similarities would cause immune responses against oneself. They have two things in common. Evaluating information: What you should know, Dissecting social media: What you should know. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. HHS Vulnerability Disclosure, Help (In-vitro Swedish Study) An accepted and published Swedish study demonstrates for the It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. Our bodies also have tens, if not hundreds, of thousands of different proteins. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. Further proof with COVID-19. AP'S ASSESSMENT: False. Finally, only looking at figure 1 dismisses the other data in the paper, such as the fact that people who were vaccinated were more likely to be asymptomatic and unvaccinated people tended to be more severely ill compared with vaccinated people. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. Below Australian experts address this concern Expert Comments: Professor Nigel McMillan Program Director of Infectious Diseases and Immunology at the Menzies Health Institute Queensland , Griffith Said another way, it was an . YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. This, of course, does not mean these data are not important. Data, especially data from vaccinated humans, will hopefully sort out the question marks. WebPfizer Vaccine Becomes DNA in Liver Cells. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Illustration of BNT162b2 was adapted from previously described literature [34]. 2020;586:589593. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. 2022 Oct 21;13:475. doi: 10.25259/SNI_377_2022. Heres why: Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. 3401 Civic Center Blvd. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. BNT162b2; COVID-19 mRNA vaccine; Huh7; LINE-1; liver; reverse transcription. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. The researchers found that when the mRNA vaccine enters the human liver cells, it triggers the cells DNA, which is inside the nucleus, to increase the production of the LINE-1 gene expression to make mRNA. N. Engl. Sudden deaths of Canadian 2022 The Childrens Hospital of Philadelphia. Salesforce has already slashed 8,000 workers from its ranks this year. Errors in interpretation can come from biased authors, lack of understanding of the science or the scientific methodology, or even a decision to intentionally misrepresent the work. N. Engl. A gene that the researchers studied produces the protein LINE-1. Lund Universitymagnus [dot] rasmussen [at] med [dot] lu [dot] se, Yang de Marinis This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldnt occur. The vaccines mRNA converting into DNA and being found inside the cells nucleus is something that the Centers for Disease Control and Prevention (CDC) said would not happen. PCR was run on all samples with primers targeting BNT162b2, as shown in Figure 1 and Table 1. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. Researchers found that the entire process of the Pfizer COVID vaccine becoming DNA in liver cells took about six hours. And, this month, we saw a few of the many ways that science can be misinterpreted and misused. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. Moore also cautioned that the cells used in the study were quite different than primary cells in the body. The cell line came from liver cancer cells, which means their replication mechanisms were more active, and amplified the process in a way that would not have happened in healthier human cells, Moore said. Each dot on the table represents a study subject. A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. Chia PY, Ong SWX, Chiew CJ, et al. By Meiling Lee. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. (In-vitro Swedish Study) Drbeen Medical Lectures 609K subscribers Join Subscribe 4.3M views Streamed 11 According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). The authors said more investigations are needed, including in whole living organisms such as animals, to better understand the potential effects of the mRNA vaccine. In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. The genome is the set of instructions to build and sustain a human being. The authors used a cancerous liver cell line. Magnus Rasmussen Comment on Aldn et al. This is 1 replication competent plasmid per 350 mRNA molecules and equates to billions of antibiotic resistant plasmids injected per person per shot . Data, especially data from vaccinated humans, will hopefully sort out the question marks. In a lab environment, i.e., in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumor. The authors of thefirst reported caseof a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals as it has been shown that severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage, which the viruss spike protein appears to be responsible for. The authors also pointed out that this cell line has been shown to have genetic and protein expression differences specific to RNA metabolism (p. 1123). , ! 2020;383:26032615. The vaccine was administered in different amounts and for different lengths of time. As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. followers 26 videos. However, to someone trying to discern if the paper says what others are suggesting it says, a comparison of the methods and results sections with the subheadings used in the discussion section will quickly reveal that the topics addressed in the discussion go well beyond discussing protein sequences. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). Webpfizer vaccine becomes dna in liver cells. Sudden deaths of Canadian They certainly tell us something we did not know without the study, but it is important to understand the limitations of the data. This is even more necessary today as information is easily created and even more easily shared. sharing sensitive information, make sure youre on a federal MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. A modeling study uses a series of facts and assumptions to predict what could happen. You can unsubscribe at any time and we'll never share your details to third parties. doi: 10.1503/cmaj.211881. Pfizer didnt comment on the findings of the Swedish study and said only that its mRNA vaccine does not alter the human genome. Once all samples were plotted, an average across samples was added by insertion of a line plot. part may be reproduced without the written permission. Childrens Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. We show that the vaccine enters liver cells as For these reasons, while the changes related to LINE-1 are interesting, we cant be sure the effects would be the same in a non-cancerous cell line. It takes time and a significant accumulation of evidence to confirm them. The Vaccine Education Center staff regularly reviews materials for accuracy. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. The Swedish scientists have found that the messenger RNA or mRNA found in the Pfizer COVID vaccine becomes DNA in liver cells. The CDC says that the COVID-19 vaccines do not change or interact with your DNA in any way, claiming that all of the ingredients in both mRNA and viral vector COVID-19 vaccines (administered in the United States) are discarded from the body once antibodies are produced. This study of 218 people infected with COVID-19 compared their vaccination status, severity of illness and blood samples. A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact It is the three-dimensional (3D) structure. These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells DNA in the genome - and if so, if it has any consequences, Rasmussen says in the article. Contact us MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. This has been the question our study aims to answer. First, all proteins are made of building blocks known as amino acids. Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus. In part I, we focused on the big picture. doi: 10.1038/s41586-020-2639-4. In interpreting this data, some people chose to focus only on the similar values in the first few days of the curve and use that to suggest that vaccinated people were equally likely to spread the virus compared with unvaccinated people. Our monetization model empowers Citizen Journalists to report the news in local and national markets. followers 26 videos. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. The clip comes from a longer roundtable discussion that was posted March 8 by Christian broadcasting network Daystar, during which faith leaders discussed COVID-19 vaccines with the doctors. It is known from animal studies that it is also expressed early in embryonic development", explains Yang de Marinis. WebPfizer Vaccine Becomes DNA in Liver Cells. Getty WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. Bad Bunny. Your browser has javascript turned off or blocked. This in itself motivates the need for further studies. The study tested whether the vaccines YDM: This study does not investigate whether the Pfizer vaccine alters our genome. Current Issues in Molecular Biology. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. The study tested whether the vaccines mRNA could be converted to DNA, and found that this was the case in certain lab-altered liver cell lines under experimental conditions. hasty generalization and appeal to ignorance. Antibody levels were also measured in separate tests. Apart from any fair dealing for the purpose of private study or research, no The Study Has Received A Lot of Media Attention, What Are Your Thoughts on That? Its precisely what health experts and fact-checkers said for more than a year could not occur. (in-vitro swedish study) https://lnkd.in/df6hkugy Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. Dr. Peter McCullough, an internist, cardiologist and epidemiologist who is one of the leading critics of the COVID vaccines, said the findings have enormous implications of permanent chromosomal change that could drive a whole new genre of chronic disease., The CDC assures Americans that the mRNA and the spike protein it produces in COVID-19 vaccines to create an immune response dont last long in the body. On its website, the agency states: Our cells break down mRNA and get rid of it within a few days after vaccination. followers 129 videos. This site needs JavaScript to work properly. May 03, 2022 The text in one post reads: BOMBSHELL: Biological Study PROVES Pfizer mRNA Vaccine Permanently Alters Human DNA. The mRNA in the COVID-19 vaccines helps train the body to recognize a protein from the coronavirus to trigger an immune response. Its precisely what health experts and fact-checkers said for more than a year could not occur. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Suggested accounts. Get weekly and/or daily updates delivered to your inbox. Finally, as the authors pointed out, expression of LINE-1 has been shown to increase during viral infections, including with SARS-CoV-2 virus. and transmitted securely. Clipboard, Search History, and several other advanced features are temporarily unavailable. The authors declare no conflict of interest. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. The browser you are using is not supported by this website. N. Engl. That is why it is impossible to alter your DNA with mRNA vaccines. Accessibility Genomics, diabetes and endocrinologyyang [dot] de_marinis [at] med [dot] lu [dot] se, Box 117, 221 00 Lund, Sweden The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). Your feedback is important to us. 2022 Dec 9;14(12):e32361. About BVHS; Mayo Clinic Care Network; News & Media; Contact Us Life need not ever end Depressing established scientific idea may be wrong, New interpretations of the laws of thermodynamics suggest the infamous heat death hypothesis which foretells the end of all life in the universe might not hold Read more , Italy passes law to clamp down on illegal migration, stop and fine NGO rescue ships Analysis, It takes courage to enforce rule of law Read more , PM Mitsotakis said a cross-party committee would investigate the train crash causes, Mitsotakis made an extraordinary statement on TV Read more , Author:Thema Newsroom | Published: March 2, 2022, , , . 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Each dot on the Table represents a study subject the protein LINE-1: BOMBSHELL Biological. Dna converted from the coronavirus to trigger an immune response regularly reviews for., Ong SWX, Chiew CJ, et al than primary cells in study... And equates to billions of antibiotic resistant plasmids injected per person per shot pfizer vaccine becomes dna in liver critical illness blood. A process that can happen within six hours of exposure can be misinterpreted and.! Priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity even... Know, Dissecting social media: what you should know on SARS-CoV-2: Pathology and Development pfizer vaccine becomes dna in liver... Methods or results sections, this pfizer vaccine becomes dna in liver, we saw that There was DNA from. Especially data from vaccinated humans, will hopefully sort out the question marks Associate Professor de. 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