Inactivating (germ-killing) ingredients , like formaldehyde, to weaken or kill viruses, bacteria, or toxins in the vaccine. Tell your vaccination provider if the person getting the vaccine: In some cases, your health care provider may decide to postpone shingles vaccination until a future visit. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Also called Tween 80, Alkest 80, or Canarcel 80 (brand names), Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients). Murray AV, Reisinger KS, Kerzner B, Stek JE, Sausser TA, et al. Some pharmacies and clinics may still have Zostavax in stock. World Health Organization, Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production, who.int, Sep. 3, 1999, ProCon/Encyclopaedia Britannica, Inc. filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80). Shingrix is now covered by most health insurance plans. ZOSTAVAX contains a weakened chickenpox virus (varicella-zoster virus). Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia (PHN), the most common complication from shingles. The rash consists of blisters that typically scab over in 7 to 10 days and clears up within 2 to 4 weeks. MMR & Varicella (measles, mumps, rubella, & chickenpox), 33. Recombinant shingles vaccine provides strong protection against shingles. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. You should tell patients to expect such reactions as pain, swelling, and redness . You should still get the second dose of recombinant shingles vaccine even if you had one of these reactions after the first dose. Ask a health care provider when you need your booster shot. Call your doctor at once if you have a high fever. 2015:372:2149-2150 [Link: ]. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. CDC recommends two doses of recombinant zoster vaccine (RZV, Shingrix) to prevent shingles and related complications in adults 50 years and older. See http://www.immunize.org/visexternal icon. Package insert for Shingrix, U.S. Food and Drug Administrationpdf iconexternal icon, Shingles Vaccine Information Statement (Shingrix), National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Safety of zoster vaccine in adults from a large managed-care cohort: A Vaccine Safety Datalink study. You should get the shingles vaccine even if you: Pregnant women, some people who have medical conditions or are taking medications that could weaken the immune system (ask your doctor if you have concerns), and people with a history of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. All information these cookies collect is aggregated and therefore anonymous. 2012 Oct 19;30(47):6636-41. Grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common (17%) after patients received Shingrix. Safety of herpes zoster vaccine in the shingles prevention study: A randomized trial. Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume.". procon@eb.com, 2022 Encyclopaedia Britannica, Inc. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Thank you for taking the time to confirm your preferences. Even if you have side effects from the first dose, it is important to get the second dose to build strong protection against shingles. After you have chickenpox, the virus stays in your body and can cause shingles later in life. Common Ingredients: tris hydrochloride, tris base, glutamate (monosodium salt), proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, ascorbic acid, niacin, glutathione. Your reaction to each dose may be different; just because you have a reaction to the first dose does not mean that you will have a reaction to the second. More information on some controversial products may be found in the glossary on this page. Thank you for taking the time to confirm your preferences. A 2013 study showed that patients with a history of a previous shingles rash had the same side effects after Zostavax as those with no history of shingles. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Either administer it immediately, or store it in the refrigerator and use it within 6 hours of reconstitution. Side effects usually go away after 2 to 3 days. All information these cookies collect is aggregated and therefore anonymous. All information these cookies collect is aggregated and therefore anonymous. Healthcare providers should counsel patients about expected reactogenicity before administering Shingrix. Some people who have or will have a weakened immune system can get the second dose 1 to 2 months after the first dose. Among immunocompetent adults 50 years and older, the efficacy of two doses of Shingrix for the prevention of herpes zoster (shingles) was high among all age groups. DTap-IPV (diphtheria, tetanus, pertussis, & polio), 11. Centers for Disease Control and Prevention. Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster. Severe allergic reactions following vaccination are rare, but can be life threatening. The pain from PHN can be severe and debilitating. Influenza A (H1N1) Vaccine(swine flu), Influenza A (H1N1) 2009 Monovalent Vaccine, allantoic fluid of embryonated chicken eggs, sucrose density gradient, betapropiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, neomycin sulfate, polymyxin B, beta-propiolactone, pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, gentamicin sulfate, Manufacturer: ID Biomedical Corporation of Quebec, allantoic cavity of embryonated hens eggs, formaldehyde, sodium deoxycholate, phosphate-buffered saline solution, thimerosal, egg proteins, formaldehyde, sodium deoxycholate, Manufacturer: Novartis Vaccines and Diagnostics Limited, allantoic cavity of embryonated hens eggs, neomycin, polymyxin, betapropiolactone, nonylphenol ethoxylate, phosphate buffered saline, thimerosal, egg proteins, polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, non-ionic surfactant, polyethylene glycol p-isooctylphenyl ether (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, polyethylene glycol p-isooctylphenyl ether, sucrose, thimerosal, Influenza Virus Vaccine, H5N1 (for National Stockpile), embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, nonionic surfactant, polyethylene glycol p-isooctylphenyl ether (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, porcine gelatin, thimerosal, formaldehyde, polyethylene glycol pIsooctylphenyl ether, sucrose, Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted, phosphate-buffered saline solution, allantoic cavity of embryonated hens eggs, formaldehyde, sodium deoxycholate, squalene, DL--tocopherol, polysorbate 80, AS03 adjuvant emulsion, thimerosal, DL--tocopherol, polysorbate 80, ovalbumin, formaldehyde, sodium deoxycholate, Influenza A (H5N1) Monovalent Vaccine, Adjuvanted, Madin Darby Canine Kidney (MDCK) cells, culture medium, -propiolactone, cetyltrimethylammonium bromide, MF59C.1 adjuvant (MF59) [squalene, polysorbate 80, sorbitan trioleate, sodium citrate dihydrate, citric acid monohydrate] , protein other than HA, MDCK cell protein, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, -propiolactone, thimerosal, Fluad Quadrivalent Package Insert (Mar. People who currently have shingles, and women who are pregnant or breastfeeding, should wait to get Shingrix. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. Mills R, Tyring SK, Levin MJ, Parrino J, Li X, et al. DTaP (diphtheria, tetanus, & pertussis), 9. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Shingrix is a new adjuvanted, non-live recombinant shingles vaccine. SHINGRIX is a vaccine indicated for prevention of herpes zoster (HZ) (shingles): in adults aged 50 years and older. Chicago, Illinois 60654 USA, Natalie Leppard Anyone who has had chickenpox in the past can get shingles because VZV remains in the body after a person recovers from chickenpox. CDC twenty four seven. There are currently two shingles vaccines licensed and available for use in the United States: Shingrix (recombinant zoster vaccine) and Zostavax (zoster vaccine live). Also, you are more likely to have severe, long-term pain if you get shingles when you are older. The CDC recommends it for healthy adults over the age of 50, but the FDA has approved Shingrix for people 18 and older who are or who will be at increased. J Intern Med. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. We take your privacy seriously. Clin Infect Dis. The FDA approved the shingles vaccine Shingrix to prevent shingles and possible health complications. DTaP Vaccine(diphtheria, tetanus, & pertussis), Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Manufacturer: GlaxoSmithKline Biologicals, Fenton medium (containing bovine extract), Latham medium, Stainer-Scholte liquid medium, glutaraldehyde, formaldehyde, aluminum hydroxide. For most people, the second dose should be given 2 to 6 months after the first dose. VAERS is only for reporting reactions, and VAERS staff members do not give medical advice. There is currently . Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Vaccine. Shingrix is administered in two doses, usually two to six months apart. 80% of the proteins in cow's milk are casein. Basic information about the shingles vaccine, Vaccine recommendations and contraindications; composition, dosage, administration, and co-administration with other vaccines; Shingrix FAQ; storage and handling. Shingrix provides strong protection against shingles and long-term pain from the disease. Cell culture (growth) material , like eggs, to help grow the vaccine antigens. Zostavax is an FDA licensed vaccine that helps to reduce the risk of getting herpes zoster (shingles) in individuals 50 years of age and older. 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Origins of Sexual Orientation, DTap-HepB-IPV (diphtheria, tetanus, pertussis, hepatitis B, & polio), DTap-IPV (diphtheria, tetanus, pertussis, & polio), DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Hep A & Hep B (hepatitis A & hepatitis B), MMR & Varicella (measles, mumps, rubella, & chickenpox), https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad, https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist, https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok, ProQuad Frozen Formulation Recombinant Human Albumin (RHA), ProQuad Frozen Formulation Human SerumAlbumin (HSA), Fighting Measles amid the COVID-19 Pandemic, US May Lose Measles Elimination Status Due to Ongoing Outbreaks, States Rethinking Childhood Vaccine Mandates during Measles Outbreak, State-by-State: Vaccinations Required for Public School Kindergarten, State Vaccination Exemptions for Children Entering Public Schools, Vaccine Ingredients and Manufacturer Information, Employer Vaccine Mandates Top 3 Pros & Cons. in adults aged 18 years and older who are or will be at increased risk of. 2015:372(22):2087-96. VZV can reactivate many years later, causing shingles. Ann Intern Med. The two doses should be separated by two to six months. You can protect yourself against shingles. Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). CDC recommends that adults age 50 years and older receive two doses of Shingrix. You may have heard you can pass the virus to others if you get the Zostavax shingles vaccine. Human albumin is a blood plasma protein produced in the liver that, among other functions, transports hormones, fatty acids, and other compounds, and buffers pH. If you had chickenpox, the virus is still in your body. Many people have redness and swelling on their arm spanning several inches where they got the shot. CDC twenty four seven. Cookies used to make website functionality more relevant to you. Tromethamine (Tris), rice-derived recombinant human serum albumin, host cell DNA, benzonase, rice protein, 14. Local grade 3 reactions occurred in 10.7% to 14.2% of RZV recipients, and systemic grade 3 reactions occurred in 9.9% to 22.3% of RZV recipients, compared with 0% to 0.3% and 6.0% to 15.5%, respectively, among placebo recipients. CDC uses 3 systems to monitor vaccine safety: English D. Willis, Meredith Woodward, Elizabeth Brown, Zoran Popmihajlov, Patricia Saddier, Paula W. Annunziato, Neal A. Halsey, Anne A. Gershon, Herpes zoster vaccine live: A 10year review of post-marketing safety experience. Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster. 2021), allantoic cavity of embryonated hens eggs, MF59C.1 adjuvant (MF59), formaldehyde, cetyltrimethylammonium bromide (CTAB), MF59C.1 adjuvant [squalene, polysorbate 80, sorbitan trioleate, sodium citrate dihydrate, citric acid monohydrate], neomycin, kanamycin, hydrocortisone, egg protein (ovalbumin), formaldehyde, CTAB, [Editors Note: This vaccine was approved on July 2, 2021, and, as of Nov. 1, 2021, the FDA had not uploaded the package insert. 33. Otherwise, discard it. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Vaccine. People sometimes faint after medical procedures, including vaccination. 14, 2016), Mueller Hinton casein agar, Watson Scherp casamino acid media, water, thimerosal, polysaccharide from each of serogroups A, C, Y, and W-135, lactose, Meningococcal (Groups A, C, Y, W) Conjugate Vaccine, Mueller Hinton agar medium, Watson Scherp medium, carbonyldiimidazole (CDI), adipic acid dihydrazide (ADH), periodate, ammonium sulfate, formaldehyde, sodium chloride, sodium acetate, formaldehyde, Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein), soy peptone broth, casamino acids and yeast extract-based medium, chemically-defined medium, ammonium sulfate, polysorbate 80, succinate buffer, aluminum phosphate. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. These cookies may also be used for advertising purposes by these third parties. People with minor illnesses, such as a cold, may be vaccinated. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Common questions about vaccine ingredients Shingles (Herpes Zoster) Vaccination | CDC Vaccines & Preventable Diseases Home Vaccines by Disease Shingles (Herpes Zoster) Vaccination Shingles is a painful rash that usually develops on one side of the body, often the face or torso. These cookies may also be used for advertising purposes by these third parties. Get CDCs official recommended immunization schedules for children, adolescents, and adults. Prices have fluctuated slightly in 2019, with Shingrix at $185 per injection ( two injections required, between two and six months apart) and Zostavax at $296 for the single dose needed. You can review and change the way we collect information below. Shingles vaccine may be given at the same time as other vaccines. All rights reserved. Some people describe the pain as an intense burning sensation. CDC twenty four seven. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Safety and tolerability of zoster vaccine in adults 60 years old. Tdap Vaccine(tetanus, diphtheria, & pertussis), Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed, Stainer-Scholte medium, casamino acids, dimethylbeta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate, modified Muellers growth medium, aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, water, modified Latham medium derived from bovine casein, Fenton medium containing a bovine extract, formaldehyde, modified Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), Manufacturer: Pfizer Ireland Pharmaceuticals, chick embryo fibroblast (CEF) cells, formaldehyde, sucrose gradient, aluminum hydroxide, human serum albumin, aluminum hydroxide, sodium chloride, dibasic sodium phosphate, monobasic potassium phosphate, formaldehyde, sucrose, protamine sulfate, chick protein, DNA from CEF cells, neomycin, gentamicin, gelatin capsules, sucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate, Typhoid Vaccine Live Oral TTyphoid Vi Polysaccharide Vacciney21a, semisynthetic medium, casein derived raw materials, hexadecyltrimethylammonium bromide, formaldehyde, formaldehyde, phenol, polydimethylsiloxane, fatty-acid ester-based antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, water, Varivax Refrigerator Package Insert (undated), Frozen: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Refrigerator: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Frozen: sucrose, phosphate, glutamate, processed gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride. The shingles vaccine does not contain thimerosal (a preservative containing mercury). Vaccines, like any medicine, can have side effects. Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. The CDC recommends all healthy adults ages 50 years and older get two doses of the shingles vaccine to prevent shingles and problems that can develop after you've had the disease. Safety of Zostavax-A cohort study in a managed care organization. Manufacturer: Wyeth Pharmaceuticals, Inc. E. coli, fermentation growth media, polysorbate 80 (PS80), polysorbate 80, Al+ as AlPO4, histidine buffered saline, Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined, Menomune-A/C/Y/W-135 Package Insert (Mar. All information these cookies collect is aggregated and therefore anonymous. These side effects may temporarily prevent a vaccinated person from doing regular activities. Manufacturer: Emergent BioDefense Operations Lansing LLC, amino acids, vitamins, inorganic salts, sugars, proteins [including the 83kDa protective antigen (PA) protein], aluminum, benzethonium chloride, formaldehyde, glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate. If you do have side effects, you may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen. About 1 out of 10 reported grade 3 systemic reactions such as myalgia (muscle pain), fatigue (feeling tired), headache, shivering, fever, and gastrointestinal illness. CDC twenty four seven. These same fetal cells obtained from the early 1960s have continued to grow in the laboratory and are used to make . These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Shingles (also called herpes zoster) is the disease caused when the chickenpox virus reactivates. Each vaccine entry links to the manufacturers package insert that contains information about dosage, ingredient quantity, and how the vaccine is made. ProCon.org. Symptoms of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Here are the proper bibliographic citations for this page according to four style manuals (in alphabetical order): [Editor's Note: The APA citation style requires double spacing within entries. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. "Vaccine Ingredients and Manufacturer Information." Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea are common after recombinant shingles vaccine. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. Shingles, or herpes zoster, is a painful skin rash that develops on one side of the face or body. Healthcare providers and vaccine manufacturers are required by law to report certain adverse events following vaccination to VAERS; patients and caregivers can also submit reports. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist], embryonated chicken eggs, linear sucrose density gradient solution, sodium deoxycholate, formaldehyde, sodium phosphate-buffered isotonic sodium chloride solution, octoxynol-10 (TRITON 272 X-100), -tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, phosphate buffered saline, thimerosal, egg proteins (ovalbumin), polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, allantoic cavity of embryonated hens eggs, kanamycin, neomycin sulphate, formaldehyde, cetyltrimethylammonium bromide (CTAB), thimerosal, egg proteins, formaldehyde, polysorbate 80, CTAB, neomycin, kanamycin, barium, Manufacturer: Sanofi Pasteur, Inc (for Fluzone High-Dose and Fluzone Intradermal only), Fluzone Intradermal Package Insert (2017-2018), Fluzone: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 214 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose: embryonated chicken eggs, formaldehyde, inear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone High-Dose: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Intradermal: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, and -propiolactone, Manufacturer: Protein Sciences Corporation, [Editors Note: The package insert for this vaccine may be found by following the Supporting Documents older than three years Flublok link on this page: https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok], fall armyworm [Spodoptera frugiperda] cell line (expresSF+), serum-free medium [lipids, vitamins, amino acids, mineral salts], baculovirus vector (Autographa californica nuclear polyhedrosis virus), Triton X-100, sodium chloride, monobasic sodium phosphate , dibasic sodium phosphate, polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Flublok Quadrivalent Package Insert (Mar.